van der Vorst, E. P. C., Theodorou, K., Wu, Y., Hoeksema, M. A., Goossens, P., Bursill, C. A., et al. (2017). High-Density Lipoproteins Exert Pro-inflammatory Effects on Macrophages via Passive Cholesterol Depletion and PKC-NF-κB/STAT1-IRF1 Signaling. Cell Metabolism, 25(1), 197–207. http://doi.org/10.1016/j.cmet.2016.10.013

van den Berg, S. M., van Dam, A. D., Rensen, P. C. N., de Winther, M. P. J., & Lutgens, E. (2016b). Immune modulation of brown(ing) adipose tissue in obesity. Endocrine Reviews, er20161066. http://doi.org/10.1210/er.2016-1066

Hoeksema, M. A., & de Winther, M. P. J. (2016). Epigenetic Regulation of Monocyte and Macrophage Function. Antioxidants & Redox Signaling, ars.2016.6695. http://doi.org/10.1089/ars.2016.6695

Winkels, H., Meiler, S., Smeets, E., Lievens, D., Engel, D., Spitz, C., et al. (2017). CD70 limits atherosclerosis and promotes macrophage function. Thrombosis and Haemostasis, 117(1), 164–175. http://doi.org/10.1160/TH16-04-0318

van den Bossche, J., Baardman, J., Otto, N. A., van der Velden, S., Neele, A. E., van den Berg, S. M., et al. (2016). Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages. Cell Reports, 17(3), 684–696. http://doi.org/10.1016/j.celrep.2016.09.008

Ahmed, M., de Winther, M. P. J., & van den Bossche, J. (2016). Epigenetic mechanisms of macrophage activation in type 2 diabetes. Immunobiology. http://doi.org/10.1016/j.imbio.2016.08.011

Stöger, J. L., Boshuizen, M. C. S., Brufau, G., Gijbels, M. J. J., Wolfs, I. M. J., van der Velden, S., et al. (2016). Deleting myeloid IL-10 receptor signalling attenuates atherosclerosis in LDLR-/- mice by altering intestinal cholesterol fluxes. Thrombosis and Haemostasis, 116(3), 565–577. http://doi.org/10.1160/TH16-01-0043

van Dam, A. D., Bekkering, S., Crasborn, M., van Beek, L., van den Berg, S. M., Vrieling, F., et al. (2016). BCG lowers plasma cholesterol levels and delays atherosclerotic lesion progression in mice. Atherosclerosis, 251, 6–14. http://doi.org/10.1016/j.atherosclerosis.2016.05.031

Allijn, I. E., Vaessen, S. F. C., Quarles van Ufford, L. C., Beukelman, K. J., de Winther, M. P. J., Storm, G., & Schiffelers, R. M. (2016). Head-to-Head Comparison of Anti-Inflammatory Performance of Known Natural Products In Vitro. PloS One, 11(5), e0155325. http://doi.org/10.1371/journal.pone.0155325

Hoeksema, M. A., Laan, L. C., Postma, J. J., Cummings, R. D., de Winther, M. P. J., Dijkstra, C. D., et al. (2016). Treatment with Trichuris suis soluble products during monocyte-to-macrophage differentiation reduces inflammatory responses through epigenetic remodeling. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 30(8), fj.201600343R–2836. http://doi.org/10.1096/fj.201600343R

van der Valk, F. M., Schulte, D. M., Meiler, S., Tang, J., Zheng, K. H., van den Bossche, J., et al. (2016). Liposomal prednisolone promotes macrophage lipotoxicity in experimental atherosclerosis. Nanomedicine : Nanotechnology, Biology, and Medicine, 12(6), 1463–1470. http://doi.org/10.1016/j.nano.2016.02.022

Boshuizen, M. C. S., Neele, A. E., Gijbels, M. J. J., van der Velden, S., Hoeksema, M. A., Forman, R. A., et al. (2016). Myeloid interferon-γ receptor deficiency does not affect atherosclerosis in LDLR(-/-) mice. Atherosclerosis, 246, 325–333. http://doi.org/10.1016/j.atherosclerosis.2016.01.026

de Winther, M. P. J. (2016). The Plot Thickens Further for Type I Interferons in Atherosclerotic Disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(2), 217–218. http://doi.org/10.1161/ATVBAHA.115.306907

van den Berg, S. M., Seijkens, T. T. P., Kusters, P. J. H., Beckers, L., Toom, den, M., Smeets, E., et al. (2016a). Diet-induced obesity in mice diminishes hematopoietic stem and progenitor cells in the bone marrow. The FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 30(5), 1779–1788. http://doi.org/10.1096/fj.201500175

Van den Bossche J, Baardman J, de Winther MPJ. Metabolic Characterization of Polarized M1 and M2 Bone Marrow-derived Macrophages Using Real-time Extracellular Flux Analysis. J Vis Exp. 2015;(105):e53424-e53424.

Baardman J, Licht I, de Winther MP, van den Bossche J. Metabolic-epigenetic crosstalk in macrophage activation. Epigenomics. 2015;7(7):epi.15.71-epi.15.1164.

Boshuizen MCS, Hoeksema MA, Neele AE, van der Velden S, Hamers AAJ, van den Bossche J, Lutgens E, de Winther MPJ. Interferon-β promotes macrophage foam cell formation by altering both cholesterol influx and efflux mechanisms. Cytokine. 2015;77:220-226.

K. Szilagyi, R. P. Gazendam, J. L. van Hamme, A. T. J. Tool, M. van Houdt, W. A. J. W. Vos, P. Verkuijlen, H. Janssen, A. Belot, L. Juillard, E. Förster-Waldl, K. Boztug, G. Kraal, M. P. J. de Winther, T. W. Kuijpers, and T. K. van den Berg, “Impaired microbial killing by neutrophils from patients with protein kinase C delta deficiency.,” J. Allergy Clin. Immunol., vol. 0, no. 0, Jul. 2015.

P. F. A. Teunissen, M. C. Boshuizen, M. R. Hollander, P. S. Biesbroek, N. W. van der Hoeven, J.-Q. Mol, M. J. Gijbels, S. van der Velden, T. C. van der Pouw Kraan, A. J. Horrevoets, M. P. de Winther, and N. van Royen, “MAb therapy against the IFN-α/β receptor subunit 1 stimulates arteriogenesis in a murine hindlimb ischaemia model without enhancing atherosclerotic burden.,” Cardiovasc Res, vol. 107, no. 2, pp. 255–266, Jul. 2015.

M. C. S. Boshuizen and M. P. J. de Winther, “Interferons as Essential Modulators of Atherosclerosis.,” Arterioscler Thromb Vasc Biol, vol. 35, no. 7, pp. 1579–1588, Jul. 2015.

A. E. Neele, J. van den Bossche, M. A. Hoeksema, and M. P. J. de Winther, “Epigenetic pathways in macrophages emerge as novel targets in atherosclerosis.,” Eur. J. Pharmacol., May 2015.

A. D. van Dam, K. J. Nahon, S. Kooijman, S. M. van den Berg, A. A. Kanhai, T. Kikuchi, M. M. Heemskerk, V. van Harmelen, M. Lombès, A. M. van den Hoek, M. P. J. de Winther, E. Lutgens, B. Guigas, P. C. N. Rensen, and M. R. Boon, “Salsalate activates brown adipose tissue in mice.,” Diabetes, vol. 64, no. 5, pp. 1544–1554, May 2015.

S. M. van den Berg, T. T. P. Seijkens, P. J. H. Kusters, B. Zarzycka, L. Beckers, M. den Toom, M. J. J. Gijbels, A. Chatzigeorgiou, C. Weber, M. P. J. de Winther, T. Chavakis, G. A. F. Nicolaes, and E. Lutgens, “Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.,” Int J Obes (Lond), vol. 39, no. 5, pp. 782–790, May 2015.

M. A. Hoeksema, B. P. Scicluna, M. C. S. Boshuizen, S. van der Velden, A. E. Neele, J. van den Bossche, H. L. Matlung, T. K. van den Berg, P. Goossens, and M. P. J. de Winther, “IFN-γ priming of macrophages represses a part of the inflammatory program and attenuates neutrophil recruitment.,” J Immunol, vol. 194, no. 8, pp. 3909–3916, Apr. 2015.

E. P. C. van der Vorst, M. Jeurissen, I. M. J. Wolfs, A. Keijbeck, K. Theodorou, E. Wijnands, L. Schurgers, S. Weber, M. J. Gijbels, A. A. J. Hamers, D. Dreymueller, S. Rose-John, M. P. J. de Winther, A. Ludwig, P. Saftig, E. A. L. Biessen, and M. M. P. C. Donners, “Myeloid A disintegrin and metalloproteinase domain 10 deficiency modulates atherosclerotic plaque composition by shifting the balance from inflammation toward fibrosis.,” Am J Pathol, vol. 185, no. 4, pp. 1145–1155, Apr. 2015.

K. Szilagyi, M. J. J. Gijbels, S. van der Velden, S. E. M. Heinsbroek, G. Kraal, M. P. J. de Winther, and T. K. van den Berg, “Dectin-1 deficiency does not affect atherosclerosis development in mice.,” Atherosclerosis, vol. 239, no. 2, pp. 318–321, Apr. 2015.

L. M. Kornmann, A. Zernecke, D. M. J. Curfs, B. J. A. Janssen, C. Weber, M. P. J. de Winther, R. S. Reneman, A. P. G. Hoeks, and K. D. Reesink, “Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study.,” Cardiovasc Ultrasound, vol. 13, no. 1, p. 1, 2015.

J. van den Bossche, A. E. Neele, M. A. Hoeksema, F. de Heij, M. C. S. Boshuizen, S. van der Velden, V. C. de Boer, K. A. Reedquist, and M. P. J. de Winther, “Inhibiting epigenetic enzymes to improve atherogenic macrophage functions.,” Biochem Biophys Res Commun, vol. 455, no. 3, pp. 396–402, Dec. 2014.

K. Szilagyi, A. B. Meijer, A. E. Neele, P. Verkuijlen, M. Leitges, S. Dabernat, E. Förster-Waldl, K. Boztug, A. Belot, T. W. Kuijpers, G. Kraal, M. P. J. de Winther, and T. K. van den Berg, “PKCδ is dispensible for oxLDL uptake and foam cell formation by human and murine macrophages.,” Cardiovasc Res, vol. 104, no. 3, pp. 467–476, Dec. 2014.

J. van den Bossche, A. E. Neele, M. A. Hoeksema, and M. P. J. de Winther, “Macrophage polarization: the epigenetic point of view.,” Curr. Opin. Lipidol., vol. 25, no. 5, pp. 367–373, Oct. 2014.

M. A. Hoeksema, M. J. Gijbels, J. van den Bossche, S. van der Velden, A. Sijm, A. E. Neele, T. Seijkens, J. L. Stöger, S. Meiler, M. C. Boshuizen, G. M. Dallinga-Thie, J. H. Levels, L. Boon, S. E. Mullican, N. J. Spann, J. P. Cleutjens, C. K. Glass, M. A. Lazar, C. J. de Vries, E. A. Biessen, M. J. Daemen, E. Lutgens, and M. P. de Winther, “Targeting macrophage Histone deacetylase 3 stabilizes atherosclerotic lesions.,” EMBO Mol Med, vol. 6, no. 9, pp. 1124–1132, Jul. 2014.

A. Chatzigeorgiou, T. Seijkens, B. Zarzycka, D. Engel, M. Poggi, S. van den Berg, S. van den Berg, O. Soehnlein, H. Winkels, L. Beckers, D. Lievens, A. Driessen, P. Kusters, E. Biessen, R. Garcia-Martin, A. Klotzsche-von Ameln, M. Gijbels, R. Noelle, L. Boon, T. Hackeng, K. Schulte, A. Xu, G. Vriend, S. Nabuurs, K.-J. Chung, K. Willems van Dijk, P. C. N. Rensen, N. Gerdes, M. de Winther, N. L. Block, A. V. Schally, C. Weber, S. R. Bornstein, G. Nicolaes, T. Chavakis, and E. Lutgens, “Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance.,” Proceedings of the National Academy of Sciences, vol. 111, no. 7, pp. 2686–2691, Feb. 2014.

M. P. J. de Winther and E. Lutgens, “MiR-92a: at the heart of lipid-driven endothelial dysfunction.,” Circ Res, vol. 114, no. 3, pp. 399–401, Jan. 2014.

T. Seijkens, M. A. Hoeksema, L. Beckers, E. Smeets, S. Meiler, J. Levels, M. Tjwa, M. P. J. de Winther, and E. Lutgens, “Hypercholesterolemia-induced priming of hematopoietic stem and progenitor cells aggravates atherosclerosis.,” The FASEB Journal, Jan. 2014.

K. A. P. Wijnands, M. A. Hoeksema, D. M. Meesters, N. M. S. van den Akker, D. G. M. Molin, J. J. Briedé, M. Ghosh, S. E. Köhler, M. A. M. J. van Zandvoort, M. P. J. de Winther, W. A. Buurman, W. H. Lamers, and M. Poeze, “Arginase-1 Deficiency Regulates Arginine Concentrations and NOS2-Mediated NO Production during Endotoxemia.,” PLoS ONE, vol. 9, no. 1, p. e86135, Jan. 2014.

C. Silvestre-Roig, M. P. de Winther, C. Weber, M. J. Daemen, E. Lutgens, and O. Soehnlein, “Atherosclerotic plaque destabilization: mechanisms, models, and therapeutic strategies.,” Circ Res, vol. 114, no. 1, pp. 214–226, Jan. 2014.


I. M. J. Wolfs, J. L. Stöger, P. Goossens, C. Pöttgens, M. J. J. Gijbels, E. Wijnands, E. P. C. van der Vorst, P. van Gorp, L. Beckers, D. Engel, E. A. L. Biessen, G. Kraal, I. van Die, M. M. P. C. Donners, and M. P. J. de Winther, “Reprogramming macrophages to an anti-inflammatory phenotype by helminth antigens reduces murine atherosclerosis.,” The FASEB Journal, vol. 28, no. 1, pp. 288–299, Jan. 2014.

N. Jetten, S. Verbruggen, M. J. Gijbels, M. J. Post, M. P. J. de Winther, and M. M. P. C. Donners, “Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo.,” Angiogenesis, vol. 17, no. 1, pp. 109–118, Jan. 2014.

P. V. Tilstam, M. J. Gijbels, M. Habbeddine, C. Cudejko, Y. Asare, W. Theelen, B. Zhou, Y. Döring, M. Drechsler, L. Pawig, S. Simsekyilmaz, R. R. Koenen, M. P. J. de Winther, T. Lawrence, J. Bernhagen, A. Zernecke, C. Weber, and H. Noels, “Bone marrow-specific knock-in of a non-activatable ikkα kinase mutant influences haematopoiesis but not atherosclerosis in apoe-deficient mice.,” PLoS ONE, vol. 9, no. 2, p. e87452, 2014.

S. Heymans, M. F. Corsten, W. Verhesen, P. Carai, R. E. W. van Leeuwen, K. Custers, T. Peters, M. Hazebroek, L. Stöger, E. Wijnands, B. J. Janssen, E. E. Creemers, Y. M. Pinto, D. Grimm, N. Schürmann, E. Vigorito, T. Thum, F. Stassen, X. Yin, M. Mayr, L. J. de Windt, E. Lutgens, K. Wouters, M. P. J. de Winther, S. Zacchigna, M. Giacca, M. van Bilsen, A.-P. Papageorgiou, and B. Schroen, “Macrophage microRNA-155 promotes cardiac hypertrophy and failure.,” Circulation, vol. 128, no. 13, pp. 1420–1432, Sep. 2013.

F. M. E. Segers, B. den Adel, I. Bot, L. M. van der Graaf, E. P. van der Veer, W. Gonzalez, I. Raynal, M. de Winther, W. K. Wodzig, R. E. Poelmann, T. J. C. van Berkel, L. van der Weerd, and E. A. L. Biessen, “Scavenger receptor-AI-targeted iron oxide nanoparticles for in vivo MRI detection of atherosclerotic lesions.,” Arterioscler Thromb Vasc Biol, vol. 33, no. 8, pp. 1812–1819, Aug. 2013.

Y. Asare, E. Shagdarsuren, J. A. Schmid, P. V. Tilstam, J. Grommes, O. El Bounkari, A. K. Schütz, C. Weber, M. P. J. de Winther, H. Noels, and J. Bernhagen, “Endothelial CSN5 impairs NF-κB activation and monocyte adhesion to endothelial cells and is highly expressed in human atherosclerotic lesions.,” Thromb Haemost, vol. 110, no. 1, pp. 141–152, Jul. 2013.

N. Jetten, M. M. P. C. Donners, A. Wagenaar, J. P. M. Cleutjens, N. van Rooijen, M. P. J. de Winther, and M. J. Post, “Local delivery of polarized macrophages improves reperfusion recovery in a mouse hind limb ischemia model.,” PLoS ONE, vol. 8, no. 7, p. e68811, 2013.

M. van Leeuwen, M. J. Kemna, M. P. J. de Winther, L. Boon, A. M. Duijvestijn, D. Henatsch, N. A. Bos, M. J. J. Gijbels, and J. W. C. Tervaert, “Passive immunization with hypochlorite-oxLDL specific antibodies reduces plaque volume in LDL receptor-deficient mice.,” PLoS ONE, vol. 8, no. 7, p. e68039, 2013.

M. R. Boon, S. A. A. van den Berg, Y. Wang, J. van den Bossche, S. Karkampouna, M. Bauwens, M. De Saint-Hubert, G. van der Horst, S. Vukicevic, M. P. J. de Winther, L. M. Havekes, J. W. Jukema, J. T. Tamsma, G. van der Pluijm, K. W. van Dijk, and P. C. N. Rensen, “BMP7 activates brown adipose tissue and reduces diet-induced obesity only at subthermoneutrality.,” PLoS ONE, vol. 8, no. 9, p. e74083, 2013.

J. L. Stöger, M. J. J. Gijbels, S. van der Velden, M. Manca, C. M. van der Loos, E. A. L. Biessen, M. J. A. P. Daemen, E. Lutgens, and M. P. J. de Winther, “Distribution of macrophage polarization markers in human atherosclerosis.,” Atherosclerosis, vol. 225, no. 2, pp. 461–468, Dec. 2012.

E. P. C. van der Vorst, A. A. Keijbeck, M. P. J. de Winther, and M. M. P. C. Donners, “A disintegrin and metalloproteases: molecular scissors in angiogenesis, inflammation and atherosclerosis.,” Atherosclerosis, vol. 224, no. 2, pp. 302–308, Oct. 2012.

R. C. J. Langen, A. Haegens, J. H. J. Vernooy, E. F. M. Wouters, M. P. J. de Winther, H. Carlsen, C. Steele, S. E. Shoelson, and A. M. W. J. Schols, “NF-κB activation is required for the transition of pulmonary inflammation to muscle atrophy.,” Am. J. Respir. Cell Mol. Biol., vol. 47, no. 3, pp. 288–297, Sep. 2012.


M. F. Corsten, A. Papageorgiou, W. Verhesen, P. Carai, M. Lindow, S. Obad, G. Summer, S. L. M. Coort, M. Hazebroek, R. van Leeuwen, M. J. J. Gijbels, E. Wijnands, E. A. L. Biessen, M. P. J. de Winther, F. R. M. Stassen, P. Carmeliet, S. Kauppinen, B. Schroen, and S. Heymans, “MicroRNA profiling identifies microRNA-155 as an adverse mediator of cardiac injury and dysfunction during acute viral myocarditis.,” Circ Res, vol. 111, no. 4, pp. 415–425, Aug. 2012.

M. A. Hoeksema, J. L. Stöger, and M. P. J. de Winther, “Molecular pathways regulating macrophage polarization: implications for atherosclerosis.,” Curr Atheroscler Rep, vol. 14, no. 3, pp. 254–263, Jun. 2012.

A. A. J. Hamers, M. Vos, F. Rassam, G. Marinković, G. Marincovic, K. Kurakula, P. J. van Gorp, M. P. J. de Winther, M. J. J. Gijbels, V. de Waard, and C. J. M. de Vries, “Bone marrow-specific deficiency of nuclear receptor Nur77 enhances atherosclerosis.,” Circ Res, vol. 110, no. 3, pp. 428–438, Feb. 2012.


M. M. P. C. Donners, I. M. J. Wolfs, L. J. Stöger, E. P. C. van der Vorst, C. C. H. Pöttgens, S. Heymans, B. Schroen, M. J. J. Gijbels, and M. P. J. de Winther, “Hematopoietic miR155 deficiency enhances atherosclerosis and decreases plaque stability in hyperlipidemic mice.,” PLoS ONE, vol. 7, no. 4, p. e35877, 2012.

K. Wouters, C. Cudejko, M. J. J. Gijbels, L. Fuentes, K. Bantubungi, J. Vanhoutte, R. Dièvart, C. Paquet, E. Bouchaert, S. A. Hannou, F. Gizard, A. Tailleux, M. P. J. de Winther, B. Staels, and R. Paumelle, “Bone marrow p16INK4a-deficiency does not modulate obesity, glucose homeostasis or atherosclerosis development.,” PLoS ONE, vol. 7, no. 3, p. e32440, 2012.

I. M. J. Wolfs, M. M. P. C. Donners, and M. P. J. de Winther, “Differentiation factors and cytokines in the atherosclerotic plaque micro-environment as a trigger for macrophage polarisation,” Thromb Haemost, vol. 106, no. 5, pp. 763–771, 2011.

M. P. J. de Winther and P. Heeringa, “Bone marrow transplantations to study gene function in hematopoietic cells.,” Methods Mol. Biol., vol. 693, pp. 309–320, 2011.
M. J. J. Gijbels and M. P. J. de Winther, “Autopsy and histological analysis of the transgenic mouse.,” Methods Mol. Biol., vol. 693, pp. 75–87, 2011.


D. J. M. Delsing, F. P. Leijten, K. Arts, H. van Eenennaam, A. Garritsen, M. J. J. Gijbels, M. P. J. de Winther, and A. van Elsas, “Cannabinoid Receptor 2 Deficiency in Haematopoietic cells Aggravates Early Atherosclerosis in LDL Receptor Deficient Mice.,” Open Cardiovasc Med J, vol. 5, pp. 15–21, 2011.

P. Goossens, M. N. Vergouwe, M. J. J. Gijbels, D. M. J. Curfs, J. H. G. van Woezik, M. A. Hoeksema, S. Xanthoulea, P. J. M. Leenen, R. A. Rupec, M. H. Hofker, and M. P. J. de Winther, “Myeloid IκBα deficiency promotes atherogenesis by enhancing leukocyte recruitment to the plaques.,” PLoS ONE, vol. 6, no. 7, p. e22327, 2011.

Goossens P, Gijbels MJ, Zernecke A, Eijgelaar W, Vergouwe MN, van der Made I, Vanderlocht J, Beckers L, Buurman WA, Daemen MJ, Kalinke U, Weber C, Lutgens E, de Winther MP. 2010. Myeloid type I interferon signaling promotes atherosclerosis by stimulating macrophage recruitment to lesions. Cell Metab. 2010 Aug 4;12(2):142-53.

Stoger, J.L., P. Goossens, and M.P. de Winther. 2010. Macrophage heterogeneity: relevance and functional implications in atherosclerosis. Curr Vasc Pharmacol 8:233-248.

Volman, J.J., R.P. Mensink, J.D. Ramakers, M.P. de Winther, H. Carlsen, R. Blomhoff, W.A. Buurman, and J. Plat. 2010. Dietary (1-->3), (1-->4)-beta-D-glucans from oat activate nuclear factor-kappaB in intestinal leukocytes and enterocytes from mice. Nutr Res 30:40-48.

Lutgens, E., D. Lievens, L. Beckers, E. Wijnands, O. Soehnlein, A. Zernecke, T. Seijkens, D. Engel, J. Cleutjens, A.M. Keller, S.H. Naik, L. Boon, H.A. Oufella, Z. Mallat, C.L. Ahonen, R.J. Noelle, M.P. de Winther, M.J. Daemen, E.A. Biessen, and C. Weber. 2010. Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med 207:391-404.

Bieghs, V., K. Wouters, P.J. Van Gorp, M.J. Gijbels, M.P. De Winther, C.J. Binder, D. Lutjohann, M. Febbraio, K.J. Moore, M. Van Bilsen, M.H. Hofker, and R. Shiri-Sverdlov. 2010. Role of Scavenger Receptor A and CD36 in Diet-induced Nonalcoholic Steatohepatitis in Hyperlipidemic Mice. Gastroenterology

Xanthoulea, S., M. Thelen, C. Pottgens, M.J. Gijbels, E. Lutgens, and M.P. de Winther. 2009. Absence of p55 TNF receptor reduces atherosclerosis, but has no major effect on angiotensin II induced aneurysms in LDL receptor deficient mice. PLoS One 4:e6113.

van Lent, P.L., W. Hofkens, A.B. Blom, L. Grevers, A. Sloetjes, N. Takahashi, L.J. van Tits, T. Vogl, J. Roth, M.P. de Winther, and W.B. van den Berg. 2009. Scavenger receptor class A type I/II determines matrix metalloproteinase-mediated cartilage destruction and chondrocyte death in antigen-induced arthritis. Arthritis Rheum 60:2954-2965.

van Leeuwen, M., J. Damoiseaux, A. Duijvestijn, P. Heeringa, M. Gijbels, M. de Winther, and J.W. Tervaert. 2009. The IgM response to modified LDL in experimental atherosclerosis: hypochlorite-modified LDL IgM antibodies versus classical natural T15 IgM antibodies. Ann N Y Acad Sci 1173:274-279.

van der Veen, B.S., M.P. de Winther, and P. Heeringa. 2009. Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease. Antioxid Redox Signal 11:2899-2937.

Matthijsen, R.A., M.P. de Winther, D. Kuipers, I. van der Made, C. Weber, M.V. Herias, M.J. Gijbels, and W.A. Buurman. 2009. Macrophage-specific expression of mannose-binding lectin controls atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation 119:2188-2195.

Manning-Tobin, J.J., K.J. Moore, T.A. Seimon, S.A. Bell, M. Sharuk, J.I. Alvarez-Leite, M.P. de Winther, I. Tabas, and M.W. Freeman. 2009. Loss of SR-A and CD36 activity reduces atherosclerotic lesion complexity without abrogating foam cell formation in hyperlipidemic mice. Arterioscler Thromb Vasc Biol 29:19-26.

Boesten, L.S., A.S. Zadelaar, A. van Nieuwkoop, L. Hu, A.F. Teunisse, A.G. Jochemsen, B. Evers, B. van de Water, M.J. Gijbels, B.J. van Vlijmen, L.M. Havekes, and M.P. de Winther. 2009. Macrophage p53 controls macrophage death in atherosclerotic lesions of apolipoprotein E deficient mice. Atherosclerosis 207:399-404.

Xanthoulea, S., M.J. Gijbels, I. van der Made, H. Mujcic, M. Thelen, M.N. Vergouwe, M.H. Ambagts, M.H. Hofker, and M.P. de Winther. 2008. P55 tumour necrosis factor receptor in bone marrow-derived cells promotes atherosclerosis development in low-density lipoprotein receptor knock-out mice. Cardiovasc Res 80:309-318.

van Leeuwen, M., M.J. Gijbels, A. Duijvestijn, M. Smook, M.J. van de Gaar, P. Heeringa, M.P. de Winther, and J.W. Tervaert. 2008. Accumulation of myeloperoxidase-positive neutrophils in atherosclerotic lesions in LDLR-/- mice. Arterioscler Thromb Vasc Biol 28:84-89.

Kornmann, L.M., D.M. Curfs, E. Hermeling, I. van der Made, M.P. de Winther, R.S. Reneman, K.D. Reesink, and A.P. Hoeks. 2008. Perfluorohexane-loaded macrophages as a novel ultrasound contrast agent: a feasibility study. Mol Imaging Biol 10:264-270.

Groeneweg, M., M.N. Vergouwe, P.G. Scheffer, H.P. Vermue, M.D. Sollewijn Gelpke, A.M. Sijbers, N. Leitinger, M.H. Hofker, and M.P. de Winther. 2008. Modification of LDL with oxidized 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (oxPAPC) results in a novel form of minimally modified LDL that modulates gene expression in macrophages. Biochim Biophys Acta 1781:336-343.

Gareus, R., E. Kotsaki, S. Xanthoulea, I. van der Made, M.J. Gijbels, R. Kardakaris, A. Polykratis, G. Kollias, M.P. de Winther, and M. Pasparakis. 2008. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 8:372-383.

Curfs, D.M., S.A. Ghesquiere, M.N. Vergouwe, I. van der Made, M.J. Gijbels, D.R. Greaves, J.S. Verbeek, M.H. Hofker, and M.P. de Winther. 2008. Macrophage secretory phospholipase A2 group X enhances anti-inflammatory responses, promotes lipid accumulation, and contributes to aberrant lung pathology. J Biol Chem 283:21640-21648.

Knaapen, A.M., D.M. Curfs, D.M. Pachen, R.W. Gottschalk, M.P. de Winther, M.J. Daemen, and F.J. Van Schooten. 2007. The environmental carcinogen benzo[a]pyrene induces expression of monocyte-chemoattractant protein-1 in vascular tissue: a possible role in atherogenesis. Mutat Res 621:31-41.

Beckers, L., S. Heeneman, L. Wang, L.C. Burkly, M.M. Rousch, N.O. Davidson, M.J. Gijbels, M.P. de Winther, M.J. Daemen, and E. Lutgens. 2007. Disruption of hedgehog signalling in ApoE - /- mice reduces plasma lipid levels, but increases atherosclerosis due to enhanced lipid uptake by macrophages. J Pathol 212:420-428.

Plat, J., I. Beugels, M.J. Gijbels, M.P. de Winther, and R.P. Mensink. 2006. Plant sterol or stanol esters retard lesion formation in LDL receptor-deficient mice independent of changes in serum plant sterols. J Lipid Res 47:2762-2771.

Lutgens, S.P., N. Kisters, E. Lutgens, R.I. van Haaften, C.T. Evelo, M.P. de Winther, P. Saftig, M.J. Daemen, S. Heeneman, and K.B. Cleutjens. 2006. Gene profiling of cathepsin K deficiency in atherogenesis: profibrotic but lipogenic. J Pathol 210:334-343.

Lutgens, E., S.P. Lutgens, B.C. Faber, S. Heeneman, M.M. Gijbels, M.P. de Winther, P. Frederik, I. van der Made, A. Daugherty, A.M. Sijbers, A. Fisher, C.J. Long, P. Saftig, D. Black, M.J. Daemen, and K.B. Cleutjens. 2006. Disruption of the cathepsin K gene reduces atherosclerosis progression and induces plaque fibrosis but accelerates macrophage foam cell formation. Circulation 113:98-107.

Groeneweg, M., E. Kanters, M.N. Vergouwe, H. Duerink, G. Kraal, M.H. Hofker, and M.P. de Winther. 2006. Lipopolysaccharide-induced gene expression in murine macrophages is enhanced by prior exposure to oxLDL. J Lipid Res 47:2259-2267.

Boesten, L.S., A.S. Zadelaar, A. van Nieuwkoop, L. Hu, J. Jonkers, B. van de Water, M.J. Gijbels, I. van der Made, M.P. de Winther, L.M. Havekes, and B.J. van Vlijmen. 2006. Macrophage retinoblastoma deficiency leads to enhanced atherosclerosis development in ApoE-deficient mice. FASEB J 20:953-955.

Xanthoulea, S., D.M. Curfs, M.H. Hofker, and M.P. de Winther. 2005. Nuclear factor kappa B signaling in macrophage function and atherogenesis. Curr Opin Lipidol 16:536-542.

Smook, M.L., P. Heeringa, J.G. Damoiseaux, M.J. Daemen, M.P. de Winther, M.J. Gijbels, L. Beckers, E. Lutgens, and J.W. Tervaert. 2005. Leukocyte CD40L deficiency affects the CD25(+) CD4 T cell population but does not affect atherosclerosis. Atherosclerosis 183:275-282.

Ghesquiere, S.A., M.H. Hofker, and M.P. de Winther. 2005. The role of phospholipases in lipid modification and atherosclerosis. Cardiovasc Toxicol 5:161-182.

Ghesquiere, S.A., M.J. Gijbels, M. Anthonsen, P.J. van Gorp, I. van der Made, B. Johansen, M.H. Hofker, and M.P. de Winther. 2005. Macrophage-specific overexpression of group IIa sPLA2 increases atherosclerosis and enhances collagen deposition. J Lipid Res 46:201-210.

de Winther, M.P., E. Kanters, G. Kraal, and M.H. Hofker. 2005. Nuclear factor kappaB signaling in atherogenesis. Arterioscler Thromb Vasc Biol 25:904-914.

Boesten, L.S., A.S. Zadelaar, A. van Nieuwkoop, M.J. Gijbels, M.P. de Winther, L.M. Havekes, and B.J. van Vlijmen. 2005. Tumor necrosis factor-alpha promotes atherosclerotic lesion progression in APOE*3-Leiden transgenic mice. Cardiovasc Res 66:179-185.

Kanters, E., M.J. Gijbels, I. van der Made, M.N. Vergouwe, P. Heeringa, G. Kraal, M.H. Hofker, and M.P. de Winther. 2004. Hematopoietic NF-kappaB1 deficiency results in small atherosclerotic lesions with an inflammatory phenotype. Blood 103:934-940.

Kanters, E., M. Pasparakis, M.J. Gijbels, M.N. Vergouwe, I. Partouns-Hendriks, R.J. Fijneman, B.E. Clausen, I. Forster, M.M. Kockx, K. Rajewsky, G. Kraal, M.H. Hofker, and M.P. de Winther. 2003. Inhibition of NF-kappaB activation in macrophages increases atherosclerosis in LDL receptor-deficient mice. J Clin Invest 112:1176-1185.

Gijbels, M.J., and M.P. de Winther. 2003. Autopsy and histologic analysis of the transgenic mouse. Methods Mol Biol 209:267-279.

de Winther, M.P., and P. Heeringa. 2003. Bone marrow transplantations to study gene function in hematopoietic cells. Methods Mol Biol 209:281-292.

Cullen, P., R. Baetta, S. Bellosta, F. Bernini, G. Chinetti, A. Cignarella, A. von Eckardstein, A. Exley, M. Goddard, M. Hofker, E. Hurt-Camejo, E. Kanters, P. Kovanen, S. Lorkowski, W. McPheat, M. Pentikainen, J. Rauterberg, A. Ritchie, B. Staels, B. Weitkamp, and M. de Winther. 2003. Rupture of the atherosclerotic plaque: does a good animal model exist? Arterioscler Thromb Vasc Biol 23:535-542.

Peiser, L., M.P. De Winther, K. Makepeace, M. Hollinshead, P. Coull, J. Plested, T. Kodama, E.R. Moxon, and S. Gordon. 2002. The class A macrophage scavenger receptor is a major pattern recognition receptor for Neisseria meningitidis which is independent of lipopolysaccharide and not required for secretory responses. Infect Immun 70:5346-5354.

de Winther, M.P., and M.H. Hofker. 2002. New mouse models for lipoprotein metabolism and atherosclerosis. Curr Opin Lipidol 13:191-197.

Bellosta, S., F. Bernini, G. Chinetti, A. Cignarella, P. Cullen, A. von Eckardstein, A. Exley, J. Freeth, M. Goddard, M. Hofker, E. Kanters, P. Kovanen, S. Lorkowski, M. Pentikainen, J. Printen, J. Rauterberg, A. Ritchie, B. Staels, B. Weitkamp, and M. de Winther. 2002. Macrophage function and stability of the atherosclerotic plaque: progress report of a European project. Nutr Metab Cardiovasc Dis 12:3-11.

Van Eck, M., M.P. De Winther, N. Herijgers, L.M. Havekes, M.H. Hofker, P.H. Groot, and T.J. Van Berkel. 2000. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on cholesterol levels and atherosclerosis in ApoE-deficient mice. Arterioscler Thromb Vasc Biol 20:2600-2606.

Herijgers, N., M.P. de Winther, M. Van Eck, L.M. Havekes, M.H. Hofker, P.M. Hoogerbrugge, and T.J. Van Berkel. 2000. Effect of human scavenger receptor class A overexpression in bone marrow-derived cells on lipoprotein metabolism and atherosclerosis in low density lipoprotein receptor knockout mice. J Lipid Res 41:1402-1409.

de Winther, M.P., K.W. van Dijk, L.M. Havekes, and M.H. Hofker. 2000. Macrophage scavenger receptor class A: A multifunctional receptor in atherosclerosis. Arterioscler Thromb Vasc Biol 20:290-297.

de Winther, M.P., and M.H. Hofker. 2000. Scavenging new insights into atherogenesis. J Clin Invest 105:1039-1041.

De Winther, M.P., M.J. Gijbels, K.W. Van Dijk, L.M. Havekes, and M.H. Hofker. 2000. Transgenic mouse models to study the role of the macrophage scavenger receptor class A in atherosclerosis. Int J Tissue React 22:85-91.

van Dijk, K.W., B.J. van Vlijmen, M.P. de Winther, B. van 't Hof, A. van der Zee, H. van der Boom, L.M. Havekes, and M.H. Hofker. 1999. Hyperlipidemia of ApoE2(Arg(158)-Cys) and ApoE3-Leiden transgenic mice is modulated predominantly by LDL receptor expression. Arterioscler Thromb Vasc Biol 19:2945-2951.

de Winther, M.P., K.W. van Dijk, B.J. van Vlijmen, M.J. Gijbels, J.J. Heus, E.R. Wijers, A.C. van den Bos, M. Breuer, R.R. Frants, L.M. Havekes, and M.H. Hofker. 1999. Macrophage specific overexpression of the human macrophage scavenger receptor in transgenic mice, using a 180-kb yeast artificial chromosome, leads to enhanced foam cell formation of isolated peritoneal macrophages. Atherosclerosis 147:339-347.

de Winther, M.P., M.J. Gijbels, K.W. van Dijk, P.J. van Gorp, H. suzuki, T. Kodama, R.R. Frants, L.M. Havekes, and M.H. Hofker. 1999. Scavenger receptor deficiency leads to more complex atherosclerotic lesions in APOE3Leiden transgenic mice. Atherosclerosis 144:315-321.

Dantuma, N.P., M. Potters, M.P. De Winther, C.P. Tensen, F.P. Kooiman, J. Bogerd, and D.J. Van der Horst. 1999. An insect homolog of the vertebrate very low density lipoprotein receptor mediates endocytosis of lipophorins. J Lipid Res 40:973-978.

Heus, J.J., M.P. de Winther, E. van de Vosse, G.J. van Ommen, and J.T. den Dunnen. 1997. Centromeric and noncentromeric ADE2-selectable fragmentation vectors for yeast artificial chromosomes in AB1380. Genome Res 7:657-660.

Toxopeus, C., I. van Holsteijn, M.P. de Winther, D. van den Dobbelsteen, G.J. Horbach, B.J. Blaauboer, and J. Noordhoek. 1994. Role of thiol homeostasis and adenine nucleotide metabolism in the protective effects of fructose in quinone-induced cytotoxicity in rat hepatocytes. Biochem Pharmacol 48:1682-1692.