(June 2017): Postdoctoral researcher in Epigenetics of Cardiovascular Disease



Job description

Epigenetic processes are critical regulators of the immune system and are emerging as targets for diagnosis and interventions. Also in monocytes and macrophages epigenetic pathways are important in mediating responses and cellular phenotype and thereby regulate disease.
We recently obtained a transatlantic Leducq consortium grant entitled:
“Defining and targeting epigenetic pathways in monocytes and macrophages that contribute to cardiovascular disease”.
In this project eight groups from both Europe and the US collaborate. In our studies we will identify epigenetic characteristics that associate with and contribute to cardiovascular disease. Moreover, we will study interventions targeting epigenetic enzymes and perform translational investigations using mouse models and cellular systems. A particular focus of the Leducq consortium is on networking and exchange of young researchers. Candidates will have the opportunity to present their work at bi-annual meetings to be held in Europe and the US and carry out work-visits to the collaborating labs.
For the Amsterdam part of the project we are in search of a postdoctoral researcher with a strong background in molecular biology. This postdoc will study the epigenetic mechanisms that drive monocyte and macrophage function in cardiovascular disease. He/she will use state-of-the-art approaches to characterize (ChIPseq, ATACseq, (single cell) RNAseq) and edit (shRNA, CRISPR-CAS9) the epigenome, apply human and mouse cell systems and investigate mouse models for disease.

Requirements

A PhD in a related area, with a strong background in molecular biology and affinity with bioinformatics for (epi)genomics; a good publication record, drive for a career in science, team player and positive social skills.


We request
A recent or upcoming PhD in a related area, preferably with a background in molecular biology and epigenetics; a good publication record, drive for a career in science, team player and positive social skills. You will be employed on the basis of a 36-hour week. Appointment is for three years. Your salary will depend on your qualifications and experience (according to UMC-CAO).

For more info send an email through
Contact.